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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø, Søs; Panzhinskiy, Evgeniy; Kolic, Jelena; Cen, Haoning Howard; Dionne, Derek A; Dai, Xiao-Qing; Sharma, Rohit B; Elghazi, Lynda; Ellis, Cara E; Faulkner, Katharine; Marcil, Stephanie A M; Overby, Peter; Noursadeghi, Nilou; Hutchinson, Daria; Hu, Xiaoke; Li, Hong; Modi, Honey; Wildi, Jennifer S; Botezelli, J Diego; Noh, Hye Lim; Suk, Sujin; Gablaski, Brian; Bautista, Austin; Kim, Ryekjang; Cras-Méneur, Corentin; Flibotte, Stephane; Sinha, Sunita; Luciani, Dan S; Nislow, Corey; Rideout, Elizabeth J; Cytrynbaum, Eric N; Kim, Jason K; Bernal-Mizrachi, Ernesto; Alonso, Laura C; MacDonald, Patrick E; Johnson, James D.
Afiliação
  • Skovsø S; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Panzhinskiy E; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Kolic J; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Cen HH; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Dionne DA; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Dai XQ; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
  • Sharma RB; Division of Endocrinology, Diabetes and Metabolism and the Weill Center for Metabolic Health, Weill Cornell Medicine, New York, NY, USA.
  • Elghazi L; Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
  • Ellis CE; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Faulkner K; Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.
  • Marcil SAM; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Overby P; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Noursadeghi N; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Hutchinson D; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Hu X; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Li H; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Modi H; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Wildi JS; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Botezelli JD; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Noh HL; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
  • Suk S; Charles River Laboratories, Shrewsbury, MA, USA.
  • Gablaski B; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
  • Bautista A; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Kim R; Charles River Laboratories, Shrewsbury, MA, USA.
  • Cras-Méneur C; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
  • Flibotte S; Alberta Diabetes Institute and Department of Pharmacology, University of Alberta, Edmonton, Canada.
  • Sinha S; Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA.
  • Luciani DS; UBC Life Sciences Institute Bioinformatics Facility, University of British Columbia, Vancouver, BC, Canada.
  • Nislow C; UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Rideout EJ; BC Children's Hospital Research Institute, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Cytrynbaum EN; UBC Sequencing and Bioinformatics Consortium, Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Kim JK; Diabetes Research Group, Life Sciences Institute, and Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
  • Bernal-Mizrachi E; Department of Mathematics, University of British Columbia, Vancouver, BC, Canada.
  • Alonso LC; Program in Molecular Medicine University of Massachusetts Medical School, Worcester, MA, USA.
  • MacDonald PE; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
  • Johnson JD; Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine and Miami VA Health Care System, Miami, FL, USA.
Nat Commun ; 13(1): 735, 2022 02 08.
Article em En | MEDLINE | ID: mdl-35136059
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Receptor de Insulina / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Hiperinsulinismo Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Receptor de Insulina / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Hiperinsulinismo Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article