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Early pregnancy hemoglobin is associated with the risk of gestational diabetes mellitus: a retrospective cohort study.
Yong, Heng Yaw; Mohd Shariff, Zalilah; Mohd Yusof, Barakatun Nisak; Rejali, Zulida; Tee, Yvonne Yee Siang; Bindels, Jacques; van der Beek, Eline M.
Afiliação
  • Yong HY; Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
  • Mohd Shariff Z; Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
  • Mohd Yusof BN; Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
  • Rejali Z; Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia.
  • Tee YYS; Danone Specialized Nutrition (Malaysia) Sdn. Bhd., Mid Valley City, Lingkaran Syed Putra, 59200Kuala Lumpur, Malaysia.
  • Bindels J; Nutricia Research Foundation, Conradpark 3, 2441 AENieuwveen, The Netherlands.
  • van der Beek EM; Department of Pediatrics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Br J Nutr ; 128(11): 2097-2104, 2022 12 14.
Article em En | MEDLINE | ID: mdl-35139935
This study aimed to determine the association between hemoglobin (Hb) concentration and Hb change, during early to mid-pregnancy with the risk of gestational diabetes mellitus (GDM). This was a clinic-based retrospective cohort study of 1951 healthy pregnant women (18-45 years old) with a singleton gestation attending antenatal care at government health clinics. Hb concentration at first prenatal visit and each trimester was extracted from the antenatal cards. Hb changes from first prenatal visit to first and second trimester as well as from second to third trimester were calculated. Multivariate logistic regression was used with adjustment for covariates. Women with GDM had significantly higher Hb concentrations (Hb 1) at first prenatal visit (< 12 weeks) compared with non-GDM women (11·91 g/dl v.11·74 g/dl). Hb 1 and Hb changes (Hb change 2) from first prenatal visit to the second trimester (23-27th weeks) were significantly associated with GDM risk, with an adjusted OR of 1·14 (95 % CI 1·01, 1·29) and 1·25 (95 % CI 1·05, 1·49), respectively. The significant associations between Hb 1 and Hb change 2 with the risk of GDM were found among non-Malays, overweight/obese and women aged 35 years and above. Women with higher Hb concentrations in early pregnancy were at higher risk of GDM, and such association was significant among women aged 35 years and above, non-Malays and overweight/obese. This raises a potential concern for elevated Fe status in early pregnancy as a risk factor of GDM among Fe-replete women.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article