In vitro α-glucosidase inhibition by Brazilian medicinal plant extracts characterised by ultra-high performance liquid chromatography coupled to mass spectrometry.
J Enzyme Inhib Med Chem
; 37(1): 554-562, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35152818
ABSTRACT
Aiming at finding natural sources of antidiabetics agents, 15 extracts from Brazilian medicinal plants of the Atlantic Forest and Amazon region were tested against α-glucosidase enzyme. Plants were selected based on the taxonomic relationships with genera including several species with antidiabetic activity. In this screening, the extracts obtained from the flowers of Hyptis monticola and the leaves of Lantana trifolia and Lippia origanoides resulted endowed with promising anti-α-glucosidase activity. The extracts from H. monticola and from L. origanoides collected in two different areas, were characterised by ultra-high performance liquid chromatography coupled to mass spectrometry. Bioassay-guided fractionation led to the identification of several enzyme inhibiting compounds, among them the mechanism of action of naringenin and pinocembrin was investigated. The two L. origanoides extracts showed differences in bioactivity and in the phytochemical profiles. The fractionation of the extract from H. monticola led to a partial loss of the inhibitory effect.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Extratos Vegetais
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Hyptis
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Lantana
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Alfa-Glucosidases
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Inibidores de Glicosídeo Hidrolases
Tipo de estudo:
Prognostic_studies
País como assunto:
America do sul
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Brasil
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article