SARS-CoV-2 infection causes intestinal cell damage: Role of interferon's imbalance.
Cytokine
; 152: 155826, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-35158258
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the newly emerging lung disease pandemic COVID-19. This viral infection causes a series of respiratory disorders, and although this virus mainly infects respiratory cells, the small intestine can also be an important site of entry or interaction, as enterocytes highly express in angiotensin-2 converting enzyme (ACE) receptors. There are countless reports pointing to the importance of interferons (IFNs) with regard to the mediation of the immune system in viral infection by SARS-CoV-2. Thus, this review will focus on the main cells that make up the large intestine, their specific immunology, as well as the function of IFNs in the intestinal mucosa after the invasion of coronavirus-2.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Enzima de Conversão de Angiotensina 2
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SARS-CoV-2
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COVID-19
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Mucosa Intestinal
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Intestino Grosso
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article