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Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study.
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji.
Afiliação
  • Harada M; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
  • Nakajima T; Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
  • Yamada Y; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
  • Aomura D; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
  • Yamaguchi A; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
  • Sonoda K; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
  • Tanaka N; Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
  • Hashimoto K; International Relations Office, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
  • Kamijo Y; Department of Nephrology, Shinshu University Hospital, Matsumoto 390-8621, Japan.
J Clin Med ; 11(3)2022 Jan 30.
Article em En | MEDLINE | ID: mdl-35160215
ABSTRACT
Sulfatides are glycosphingolipids that are associated with coagulation and platelet aggregation. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) activates platelet function and often leads to thrombotic complications. These facts suggest an association between serum sulfatides and AAV. We aimed to clarify the significance of serum sulfatide levels in patients with AAV. We conducted a retrospective, single-center, observational pilot study that included 35 patients who developed AAV and 10 control patients who were candidates for living-donor kidney transplantation. We compared serum sulfatide levels between the control and AAV patients. We analyzed the differences in serum sulfatide levels among four classes (focal, crescentic, mixed, and sclerotic class) of glomerular lesions that were categorized by histopathologic classification of ANCA-associated glomerulonephritis. Serum sulfatide levels in patients with AAV were significantly lower than those in the controls. Serum sulfatide levels were significantly different between the four classes. Additionally, serum sulfatide levels in the crescentic class were significantly lower than those in the other classes. Serum sulfatide levels were significantly correlated with albumin, cholesterol, C-reactive protein, and pentraxin 3. In conclusion, serum sulfatide levels are significantly correlated with inflammation, reflecting crescentic glomerulonephritis, which is an active glomerular lesion in AAV patients.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article