Optimizing Therapies Using Therapeutic Drug Monitoring: Current Strategies and Future Perspectives.
Gastroenterology
; 162(5): 1512-1524, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-35167865
ABSTRACT
Therapeutic drug monitoring (TDM) has emerged as a strategy for treatment optimization in inflammatory bowel diseases to maximize benefit and to reach more stringent, objective end points. Optimal drug concentrations in inflammatory bowel disease vary according to treatment target, disease phenotype, inflammatory burden, and timing of sampling during the treatment cycle. This review provides an update on TDM with biologic and oral small molecules, evaluates the role of reactive vs proactive TDM, and identifies the gaps in current evidence. In the future, adaptations to how we use TDM may contribute further to the goal of personalized treatment in patients with IBD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Monitoramento de Medicamentos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article