Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects.
Science
; 201(4350): 73-6, 1978 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-351804
ABSTRACT
Endogenous opiate-like peptides (endorphins) are putative neuroregulators located throughout the mammalian brainstem. There is some evidence for their role in pain, stress, and affect. We report that the opiate antagonist, naloxone, alters some schizophrenic symptoms. In a double-blind, cross-over study, naloxone produced decreases in auditory hallucinations in some schizophrenic patients. This finding supports the hypothesis that the endorphins may play a roll in modulating hallucinations in a highly selected subgroup of chronically hallucinating schizophrenic patients.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Alucinações
/
Naloxona
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article