Metabolic profiling in the hypothalamus of aged mice.
Biochem Biophys Res Commun
; 599: 134-141, 2022 04 09.
Article
em En
| MEDLINE
| ID: mdl-35182939
ABSTRACT
Metabolic abnormalities are tightly connected to the perturbation of normal brain functions, thereby causing multiple neurodegenerative diseases. The hypothalamus is the master unit that controls the whole-body energy homeostasis. Thus, altered metabolic activity in the hypothalamus could be a crucial clue to better understand the development of metabolic disorders during aging. The current study aimed to investigate the changes in hypothalamic metabolites according to the aging process using gas chromatography-mass spectrometry. We identified that multiple metabolites and neurotransmitters were effectively reduced in the hypothalamus of aged mice. In addition, we observed increased levels of genes linked to the production and utilization of monocarboxylates in the aged hypothalamus, indicating the initiation of metabolic activity to produce alternative nutrient sources. Lastly, we found a reduced number of astrocytes in the hypothalamus of aged mice, suggesting that reduced nutrient availability in the hypothalamus might be associated with the decreased activity of astrocytes during aging. Collectively, the present study suggests that the deterioration of metabolic activities in the hypothalamus might be a primary cause and/or outcome of metabolic diseases associated with the aging process.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Metaboloma
/
Hipotálamo
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article