Immunohistochemical localization of apolipoprotein E in atherosclerotic lesions of the aorta and coronary arteries.
Atherosclerosis
; 60(1): 1-6, 1986 Apr.
Article
em En
| MEDLINE
| ID: mdl-3518733
ABSTRACT
The distribution of apolipoprotein E (apo E) immunoreactive substances (IRS) in atherosclerotic lesions and lesion-free areas of the aorta and coronary arteries obtained from 17 autopsied cases was studied using a specific anti-apo E serum and the unlabeled peroxidase-antiperoxidase (PAP) method. In fatty streak lesions of the aorta, many cells containing apo E-IRS were found in the deeper layer of the intima and diffuse staining of apo E in the extracellular spaces was also noted. In more advanced lesions apo E-positive cells could not be found. Immunohistochemical findings of coronary arteries differed distinctly from those of the aorta in that the apo-E-positive cells were absent in the deeper layer of the intima. The endothelial cells of coronary arteries, but not those of the aorta, showed positive staining for apo E.
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Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Apolipoproteínas E
/
Arteriosclerose
/
Vasos Coronários
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article