Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks.
J Org Chem
; 87(5): 3114-3122, 2022 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-35191705
ABSTRACT
α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of ß-chloroamines and indoles.
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MEDLINE
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En
Ano de publicação:
2022
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Article