The Impact of Compliance During Exclusive Enteral Nutrition on Faecal Calprotectin in Children With Crohn Disease.
J Pediatr Gastroenterol Nutr
; 74(6): 801-804, 2022 06 01.
Article
em En
| MEDLINE
| ID: mdl-35192573
ABSTRACT
ABSTRACT It remains unclear whether suboptimal response to exclusive enteral nutrition (EEN) in some children with Crohn disease (CD) is explained by poor compliance. The present study measured faecal gluten immunogenic peptides (GIP), a biomarker of gluten intake, in 45 children (3- 17âyears) with CD, and explored associations with faecal calprotectin (FC) levels at 33 and 54âdays of EEN. FC decreased in patients with undetectable GIP at both 33 and 54âdays of EEN (mean decrease, 33âdays -743âmg/kg, 54âdays -1043âmg/kg, Pâ <â0.001) but not in patients who had detectable levels. At EEN completion, patients with undetectable GIP had a lower FC by 717âmg/kg compared with patients with a positive GIP result (Pâ=â0.042) and demonstrated a greater decline from baseline FC (-69% vs +5%, Pâ=â0.011). Poorer response to EEN is explained in part by diminished compliance. Faecal GIP might be useful as proxy biomarker of EEN compliance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Crohn
/
Cooperação do Paciente
/
Complexo Antígeno L1 Leucocitário
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article