PDE4D targeting enhances anti-tumor effects of sorafenib in clear cell renal cell carcinoma and attenuates MAPK/ERK signaling in a CRAF-dependent manner.

Cao, Minghua; Nawalaniec, Karol; Ajay, Amrendra K; Luo, Yueming; Moench, Romana; Jin, Yanfei; Xiao, Sheng; Hsiao, Li-Li; Waaga-Gasser, Ana Maria

Cao, Minghua; Nawalaniec, Karol; Ajay, Amrendra K; Luo, Yueming; Moench, Romana; Jin, Yanfei; Xiao, Sheng; Hsiao, Li-Li; Waaga-Gasser, Ana Maria.

Afiliação

Cao M; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA; The Sixth People's Hospital of Nantong, Affiliated Nantong Hospital of Shanghai University, Nantong, Jiangsu 226011, China.
Nawalaniec K; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA.
Ajay AK; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA.
Luo Y; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA.
Moench R; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA.
Jin Y; The Sixth People's Hospital of Nantong, Affiliated Nantong Hospital of Shanghai University, Nantong, Jiangsu 226011, China.
Xiao S; Department of Pathology, Cytogenetics Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Hsiao LL; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA. Electronic address: lhsiao@bwh.harvard.edu.
Waaga-Gasser AM; Department of Medicine, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI Rm 449, Boston, MA 02115, USA. Electronic address: awaaga@bwh.harvard.edu.