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Real-world utilization and outcomes of docetaxel among older men with metastatic prostate cancer: a retrospective population-based cohort study in Canada.
Shayegan, Bobby; Wallis, Christopher J D; Hamilton, Robert J; Morgan, Scott C; Cagiannos, Ilinas; Basappa, Naveen S; Ferrario, Cristiano; Gotto, Geoffrey T; Fernandes, Ricardo; Roy, Soumyajit; Noonan, Krista L; Niazi, Tamim; Hotte, Sebastien J; Saad, Fred; Hew, Huong; Park-Wyllie, Laura; Chan, Katherine F Y; Malone, Shawn.
Afiliação
  • Shayegan B; St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.
  • Wallis CJD; Mount Sinai Hospital, Toronto, ON, Canada. wallis.cjd@gmail.com.
  • Hamilton RJ; Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.
  • Morgan SC; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
  • Cagiannos I; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
  • Basappa NS; Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
  • Ferrario C; Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada.
  • Gotto GT; Southern Alberta Institute of Urology, University of Calgary, Calgary, AB, Canada.
  • Fernandes R; London Regional Cancer Program, London, ON, Canada.
  • Roy S; Radiation Oncology, Rush University Cancer Center, Chicago, IL, USA.
  • Noonan KL; BC Cancer Agency, University of British Columbia, Surrey, BC, Canada.
  • Niazi T; Jewish General Hospital, McGill University, Montreal, QC, Canada.
  • Hotte SJ; Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.
  • Saad F; Centre Hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
  • Hew H; Janssen Inc., Toronto, ON, Canada.
  • Park-Wyllie L; Janssen Inc., Toronto, ON, Canada.
  • Chan KFY; Janssen Inc., Toronto, ON, Canada.
  • Malone S; The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Prostate Cancer Prostatic Dis ; 26(1): 74-79, 2023 03.
Article em En | MEDLINE | ID: mdl-35197558
BACKGROUND: The adoption of docetaxel for systemic treatment of metastatic prostate cancer (PCa), in both castration-sensitive (mCSPC) and castration-resistant (mCRPC) settings, is poorly understood. This study examined the real-world utilization of docetaxel in these patients and their outcomes. METHODS: A retrospective population-based study used administrative data from Ontario, Canada, to identify men aged ≥66 years who were diagnosed with de novo mCSPC or mCRPC between 2014 and 2019 and received docetaxel. The study assessed treatment tolerability and toxicity, and survival in both cohorts. Descriptive and comparative statistical analysis were conducted. RESULTS: The study identified 11.2% (399/3556) and 13.2% (203/1534) patients diagnosed with de novo mCSPC and with mCRPC who received docetaxel respectively. The median age in both cohorts was 72 years (IQR: 68-76). Overall, 43.9% (n = 175) patients with de novo mCSPC and 52.1% (n = 85) with mCRPC completed ≥6 cycles of docetaxel. Over two-fifth also needed dose adjustments in both cohorts. Hospitalization or emergency department visit for febrile neutropenia were noted in 15.8% (n = 63) of de novo mCSPC patients and similarly in 19% (n = 31) of mCRPC cohort. The median survival of PCa patients who completed ≥6 cycles of docetaxel was significantly longer relative to those who completed <4 cycles: 32.7 vs. 23.5 months (p < 0.001) for mCSPC and 20.5 vs. 10.7 (p = 0.012) for mCRPC respectively. CONCLUSIONS: In this population-based study of elderly patients with metastatic PCa, treatment with docetaxel was associated with poor tolerability and higher toxicity compared with clinical trials. Receipt of limited cycles and reduced overall dose of docetaxel were associated with inferior overall survival.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Próstata Resistentes à Castração Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article