Sarubicinols A-C, Cytotoxic Benzoxazoles from a Streptomyces.
J Nat Prod
; 85(4): 1167-1173, 2022 04 22.
Article
em En
| MEDLINE
| ID: mdl-35213166
ABSTRACT
A chemical investigation of Streptomyces sp. Hu186 afforded two known quinone antibiotics, sarubicin A (1) and sarubicin B (2), together with three unusual variants, sarubicinols A-C (3-5), and two new 1,4-naphthoquinone metabolites, sarubicin B1 (6) and sarubicin B2 (7). Compounds 3-5 possess a rare 2-oxabicyclo [2.2.2] substructure and a benzoxazole ring system. Their structures were elucidated using 1D and 2D nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data. The absolute configurations of the side-chain moieties in 4 and 5 were solved by electronic circular dichroism calculations. Compounds 1-7 showed moderate cytotoxic activity against four tumor cell lines.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article