Clostridioides difficile from Brazilian hospitals: characterization of virulence genes by whole genome sequencing.
Microbes Infect
; 24(5): 104953, 2022.
Article
em En
| MEDLINE
| ID: mdl-35217192
ABSTRACT
Clostridioides difficile (CD) is the most frequent cause of healthcare related diarrhea and its severity has increased in the last decade by the spread of hypervirulent strains. Most important CD virulence factor is toxin production; however, not only toxins are responsible for Clostridioides virulence. We sequenced 38 strains and analyzed the presence and integrity of 24 virulence (including toxin) genes. We identified 28 toxigenic strains, six also presented the cdt genes. Only six strains didn't present all others genes searched. All absent genes were adhesion related. Understand others CD virulence factors can lead to a best understanding on this matter.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
/
Clostridioides difficile
/
Infecções por Clostridium
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article