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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao, Fenghui; Zhou, Qingtong; Cong, Zhaotong; Hang, Kaini; Zou, Xinyu; Zhang, Chao; Chen, Yan; Dai, Antao; Liang, Anyi; Ming, Qianqian; Wang, Mu; Chen, Li-Nan; Xu, Peiyu; Chang, Rulve; Feng, Wenbo; Xia, Tian; Zhang, Yan; Wu, Beili; Yang, Dehua; Zhao, Lihua; Xu, H Eric; Wang, Ming-Wei.
Afiliação
  • Zhao F; School of Pharmacy, Fudan University, Shanghai, China.
  • Zhou Q; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Cong Z; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Hang K; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Zou X; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Zhang C; School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China.
  • Chen Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Dai A; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Liang A; The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Ming Q; School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China.
  • Wang M; Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Chen LN; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Xu P; Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Chang R; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Feng W; School of Pharmacy, Fudan University, Shanghai, China.
  • Xia T; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • Zhang Y; School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China.
  • Wu B; Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Yang D; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Zhao L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
  • Xu HE; University of Chinese Academy of Sciences, Beijing, China.
  • Wang MW; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. dhyang@simm.ac.cn.
Nat Commun ; 13(1): 1057, 2022 02 25.
Article em En | MEDLINE | ID: mdl-35217653
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucagon / Diabetes Mellitus Tipo 2 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Glucagon / Diabetes Mellitus Tipo 2 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article