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Gut microbiota from Mexican patients with metabolic syndrome and HIV infection: An inflammatory profile.
Amador-Lara, Fernando; Andrade-Villanueva, Jaime F; Vega-Magaña, Natali; Peña-Rodríguez, Marcela; Alvarez-Zavala, Monserrat; Sanchez-Reyes, Karina; Toscano-Piña, Marcela; Peregrina-Lucano, Alejandro A; Del Toro-Arreola, Susana; González-Hernández, Luz A; Bueno-Topete, Miriam R.
Afiliação
  • Amador-Lara F; Unidad de VIH, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.
  • Andrade-Villanueva JF; Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • Vega-Magaña N; Unidad de VIH, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.
  • Peña-Rodríguez M; Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • Alvarez-Zavala M; Laboratorio de Diagnóstico de Enfermedades Emergentes y Reemergentes (LaDEER), Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • Sanchez-Reyes K; Instituto de Investigación en Ciencias Biomédicas (IICB), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • Toscano-Piña M; Instituto de Investigación en Enfermedades Crónico-Degenerativas (IECD), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • Peregrina-Lucano AA; Unidad de VIH, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.
  • Del Toro-Arreola S; Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
  • González-Hernández LA; Unidad de VIH, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara, Mexico.
  • Bueno-Topete MR; Instituto de Investigación en Inmunodeficiencias y VIH (InIVIH), Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
J Appl Microbiol ; 132(5): 3839-3852, 2022 May.
Article em En | MEDLINE | ID: mdl-35218591
AIM: A remarkable increase in metabolic syndrome (MetS) has occurred in HIV-infected subjects. Gut dysbiosis is involved in the pathogenesis of metabolic disorders. Therefore, the aim is to explore the profile of the gut microbiota in Mexican population with HIV infection and MetS. METHODS AND RESULTS: In all, 30 HIV-infected patients with MetS were compared to a group of 30 patients without MetS, treated with integrase inhibitors and undetectable viral load were included in the study. Stool samples were analysed by 16S rRNA next-generation sequencing. High-sensitivity C-reactive protein >3 mg L-1 and higher scores in cardiometabolic indices were associated with MetS. The group with MetS was characterized by a decrease in α-diversity, higher abundance of Enterobacteriaceae and Prevotella, as well as a dramatic decrease in bacteria producing short-chain fatty acids. Prevotella negatively correlated with Akkermansia, Lactobacillus and Anaerostipes. Interestingly, the group without MetS presented higher abundance of Faecalibacterium, Ruminococcus, Anaerofilum, Oscillospira and Anaerostipes. Functional pathways related to energy metabolism and inflammation were increased in the group with MetS. CONCLUSIONS: HIV-infected patients with MetS present a strong inflammatory microbiota profile; therefore, future strategies to balance intestinal dysbiosis should be implemented.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Síndrome Metabólica / Microbioma Gastrointestinal Limite: Humans País como assunto: Mexico Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Síndrome Metabólica / Microbioma Gastrointestinal Limite: Humans País como assunto: Mexico Idioma: En Ano de publicação: 2022 Tipo de documento: Article