AKT Hyperphosphorylation and T Cell Exhaustion in Down Syndrome.

Peeters, Daphne; Pico-Knijnenburg, Ingrid; Wieringa, Douwe; Rad, Mandana; Cuperus, Roos; Ruige, Madelon; Froeling, Frank; Zijp, Gerda W; van der Burg, Mirjam; Driessen, Gertjan J A

Peeters, Daphne; Pico-Knijnenburg, Ingrid; Wieringa, Douwe; Rad, Mandana; Cuperus, Roos; Ruige, Madelon; Froeling, Frank; Zijp, Gerda W; van der Burg, Mirjam; Driessen, Gertjan J A.

Afiliação

Peeters D; Department of Pediatrics, Juliana Children's Hospital, The Hague, Netherlands.
Pico-Knijnenburg I; Department of Pediatrics, Laboratory for Pediatric Immunology, Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, Netherlands.
Wieringa D; Department of Pediatrics, Laboratory for Pediatric Immunology, Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, Netherlands.
Rad M; Department of Pediatric Anaesthesiology, Juliana Children's Hospital/Haga Teaching Hospital, The Hague, Netherlands.
Cuperus R; Department of Pediatrics, Juliana Children's Hospital, The Hague, Netherlands.
Ruige M; Department of Pediatrics, Juliana Children's Hospital, The Hague, Netherlands.
Froeling F; Department of Pediatric Urology, Juliana Children's Hospital, The Hague, Netherlands.
Zijp GW; Department of Paediatric Surgery, Juliana Children's Hospital, The Hague, Netherlands.
van der Burg M; Department of Pediatrics, Laboratory for Pediatric Immunology, Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, Netherlands.
Driessen GJA; Department of Pediatrics, Juliana Children's Hospital, The Hague, Netherlands.

Front Immunol ; 13: 724436, 2022.

Article em En | MEDLINE | ID: mdl-35222360

Assuntos

Síndrome de Down; Proteínas Proto-Oncogênicas c-akt; Linfócitos T; Criança; Pré-Escolar; Estudos de Coortes; Síndrome de Down/imunologia; Neoplasias Hematológicas; Humanos; Lactente; Fosfatidilinositol 3-Quinases; Receptor de Morte Celular Programada 1/metabolismo; Proteínas Proto-Oncogênicas c-akt/química; Linfócitos T/citologia

Palavras-chave

AKT pathway; T cell exhaustion; activated PI3 kinase delta syndrome; down syndrome; immunodeficiencies; immunophenotyping

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Síndrome de Down / Proteínas Proto-Oncogênicas c-akt Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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