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A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonance.
Chowdhury, Rafat; Papoutsaki, Marianthi-Vasiliki; Müller, Christoph A; Smith, Lorna; Gong, Fiona; Bullock, Max; Rogers, Harriet; Mathew, Manju; Syer, Tom; Singh, Saurabh; Retter, Adam; Caselton, Lucy; Ryu, Jung; Oliver-Taylor, Aaron; Golay, Xavier; Bainbridge, Alan; Gadian, David G; Punwani, Shonit.
Afiliação
  • Chowdhury R; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Papoutsaki MV; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Müller CA; Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Smith L; German Cancer Consortium (DKTK), partner site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Gong F; Gold Standard Phantoms Limited, London, UK.
  • Bullock M; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Rogers H; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Mathew M; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Syer T; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Singh S; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Retter A; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Caselton L; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Ryu J; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Oliver-Taylor A; Centre for Medical Imaging, Division of Medicine, University College London, London, UK.
  • Golay X; Gold Standard Phantoms Limited, London, UK.
  • Bainbridge A; Gold Standard Phantoms Limited, London, UK.
  • Gadian DG; Department of Brain Repair and Rehabilitation, Institute of Neurology, Queen's Square, University College London, London, UK.
  • Punwani S; Department of Medical Physics and Biomedical Engineering, University College London Hospitals, London, UK.
Br J Radiol ; 95(1134): 20210770, 2022 Jun 01.
Article em En | MEDLINE | ID: mdl-35230136
ABSTRACT

OBJECTIVE:

To develop a phantom system which can be integrated with an automated injection system, eliminating the experimental variability that arises with manual injection; for the purposes of pulse sequence testing and metric derivation in hyperpolarised 13C-MR.

METHODS:

The custom dynamic phantom was machined from Ultem and filled with a nicotinamide adenine dinucleotide and lactate dehydrogenase mixture dissolved in phosphate buffered saline. Hyperpolarised [1-13C]-pyruvate was then injected into the phantom (n = 8) via an automated syringe pump and the conversion of pyruvate to lactate monitored through a 13C imaging sequence.

RESULTS:

The phantom showed low coefficient of variation for the lactate to pyruvate peak signal heights (11.6%) and dynamic area-under curve ratios (11.0%). The variance for the lactate dehydrogenase enzyme rate constant (kP) was also seen to be low at 15.6%.

CONCLUSION:

The dynamic phantom demonstrates high reproducibility for quantification of 13C-hyperpolarised MR-derived metrics. Establishing such a phantom is needed to facilitate development of hyperpolarsed 13C-MR pulse sequenced; and moreover, to enable multisite hyperpolarised 13C-MR clinical trials where assessment of metric variability across sites is critical. ADVANCES IN KNOWLEDGE The dynamic phantom developed during the course of this study will be a useful tool in testing new pulse sequences and standardisation in future hyperpolarised work.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Ácido Pirúvico Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Ácido Pirúvico Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article