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Persistence of Depressive Symptoms and Risk of Incident Cardiovascular Disease With and Without Diabetes: Results from the REGARDS Study.
Cummings, Doyle M; Lutes, Lesley D; Wilson, J Lane; Carraway, Marissa; Safford, Monika M; Cherrington, Andrea; Long, D Leann; Carson, April P; Yuan, Ya; Howard, Virginia J; Howard, George.
Afiliação
  • Cummings DM; Department of Family Medicine, East Carolina University Brody School of Medicine, Greenville, NC, USA. cummingsd@ecu.edu.
  • Lutes LD; Department of Psychology, University of British Columbia, Kelowna, Canada.
  • Wilson JL; Department of Family Medicine, East Carolina University Brody School of Medicine, Greenville, NC, USA.
  • Carraway M; Department of Family Medicine, East Carolina University Brody School of Medicine, Greenville, NC, USA.
  • Safford MM; Department of Medicine, Weill Cornell Medical Center, New York, USA.
  • Cherrington A; Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, USA.
  • Long DL; School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
  • Carson AP; School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
  • Yuan Y; School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
  • Howard VJ; School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
  • Howard G; School of Public Health, University of Alabama at Birmingham, Birmingham, USA.
J Gen Intern Med ; 37(16): 4080-4087, 2022 12.
Article em En | MEDLINE | ID: mdl-35230623
BACKGROUND: Baseline depressive symptoms are associated with subsequent adverse cardiovascular (CV) events in subjects with and without diabetes but the impact of persistent symptoms vs. improvement remains controversial. OBJECTIVE: Examine long-term changes in depressive symptoms in individuals with and without diabetes and the associated risk for adverse CV events. DESIGN: REGARDS is a prospective cohort study of CV risk factors in 30,000 participants aged 45 years and older. PARTICIPANTS: N = 16,368 (16.5% with diabetes mellitus) who remained in the cohort an average of 11.1 years later and who had complete data. MAIN MEASURES: Depressive symptoms were measured using the 4-item Centers for Epidemiologic Study of Depression (CES-D) questionnaire at baseline and again at a mean follow-up of 5.07 (SD = 1.66) years. Adjudicated incident stroke, coronary heart disease (CHD), CV mortality, and a composite outcome were assessed in a subsequent follow-up period of 6.1 (SD = 2.6) years. METHODS: The association of changes in depressive symptoms (CES-D scores) across 5 years with incident CV events was assessed using Cox proportional hazards modeling. KEY RESULTS: Compared to participants with no depressive symptoms at either time point, participants without diabetes but with persistently elevated depressive symptoms at both baseline and follow-up demonstrated a significantly increased risk of incident stroke (HR (95% CI) = 1.84 (1.03, 3.30)), a pattern which was substantially more prevalent in blacks (HR (95% CI) = 2.64 (1.48, 4.72)) compared to whites (HR (95% CI) = 1.06 (0.50, 2.25)) and in those not taking anti-depressants (HR (95% CI) = 2.01 (1.21, 3.35)) in fully adjusted models. CONCLUSIONS: The persistence of depressive symptoms across 5 years of follow-up in participants without diabetes identifies individuals at increased risk for incident stroke. This was particularly evident in black participants and among those not taking anti-depressants.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral / Diabetes Mellitus Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral / Diabetes Mellitus Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article