Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases.

Aublette, Marine C; Harrison, Tom A; Thorpe, Elizabeth J; Gadd, Morgan S

Aublette, Marine C; Harrison, Tom A; Thorpe, Elizabeth J; Gadd, Morgan S.

Afiliação

Aublette MC; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Harrison TA; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Thorpe EJ; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom.
Gadd MS; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YG, United Kingdom. Electronic address: m.gadd@lancaster.ac.uk.

Bioorg Med Chem Lett ; 64: 128636, 2022 05 15.

Article em En | MEDLINE | ID: mdl-35231578

Assuntos

Proteólise; Ubiquitina-Proteína Ligases; Ligantes; Ubiquitina-Proteína Ligases/metabolismo; Proteínas Tirosina Quinases; Proteínas de Ciclo Celular; Reparo do DNA; Dano ao DNA

Palavras-chave

CDK1; Cereblon; Checkpoint inhibition; PROTAC; Targeted degradation; VHL; Wee1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases / Proteólise Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ubiquitina-Proteína Ligases / Proteólise Idioma: En Ano de publicação: 2022 Tipo de documento: Article