Improved Confidence in a Confirmatory Stage by Application of Item-Based Pharmacometrics Model: Illustration with a Phase III Active Comparator-Controlled Trial in COPD Patients.

Llanos-Paez, Carolina; Ambery, Claire; Yang, Shuying; Beerahee, Misba; Plan, Elodie L; Karlsson, Mats O

Llanos-Paez, Carolina; Ambery, Claire; Yang, Shuying; Beerahee, Misba; Plan, Elodie L; Karlsson, Mats O.

Afiliação

Llanos-Paez C; Department of Pharmacy, Uppsala University, BMC, Box 580, 751 23, Uppsala, Sweden.
Ambery C; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline plc, London, UK.
Yang S; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline plc, London, UK.
Beerahee M; Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline plc, London, UK.
Plan EL; Department of Pharmacy, Uppsala University, BMC, Box 580, 751 23, Uppsala, Sweden.
Karlsson MO; Department of Pharmacy, Uppsala University, BMC, Box 580, 751 23, Uppsala, Sweden. mats.karlsson@farmaci.uu.se.

Pharm Res ; 39(8): 1779-1787, 2022 Aug.

Article em En | MEDLINE | ID: mdl-35233731

Assuntos

Doença Pulmonar Obstrutiva Crônica; Administração por Inalação; Broncodilatadores/uso terapêutico; Humanos; Medidas de Resultados Relatados pelo Paciente; Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico

Palavras-chave

chronic obstructive pulmonary disease; item response theory; mixed model repeated measures; non-linear mixed effect model; patient-reported outcomes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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