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Radical S-Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S.
Lee, Yu-Hsuan; Hou, Xueli; Chen, Ridao; Feng, Jianqiang; Liu, Xiao; Ruszczycky, Mark W; Gao, Jin-Ming; Wang, Binju; Zhou, Jiahai; Liu, Hung-Wen.
Afiliação
  • Lee YH; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
  • Hou X; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi China.
  • Chen R; State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
  • Feng J; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
  • Liu X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Ruszczycky MW; State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
  • Gao JM; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
  • Wang B; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
  • Zhou J; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
  • Liu HW; Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi China.
J Am Chem Soc ; 144(10): 4478-4486, 2022 03 16.
Article em En | MEDLINE | ID: mdl-35238201
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: S-Adenosilmetionina / Desidratação Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: S-Adenosilmetionina / Desidratação Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article