Transient Clozapine-induced Myocarditis Without Discontinuation of Medication: A Series of 2 Patients.
J Psychiatr Pract
; 28(2): 170-175, 2022 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-35238829
ABSTRACT
BACKGROUND:
Clozapine, an antipsychotic medication used to treat treatment-refractory schizophrenia, has been associated with various dangerous side effects, including myocarditis. However, there have been few published cases reporting on patients with clozapine-induced myocarditis confirmed by cardiac magnetic resonance imaging or the management, treatment, and follow-up of these patients.METHODS:
This report describes 2 cases of patients with treatment-refractory schizophrenia evidencing transient clozapine-induced myocarditis. Detailed information including laboratory values, imaging results, and clinical notes were gathered.FINDINGS:
The 2 cases demonstrated differing manifestations of clozapine-induced myocarditis. Both cases showed that such myocarditis can be transient and can be treated clinically with close observation without discontinuation of clozapine. IMPLICATIONS These cases show that clozapine-induced myocarditis is transient at times and can self-resolve without discontinuation of clozapine. These observations may suggest a change in clinical practice so that, with close observation, we can avoid risking psychiatric decompensation in select patients with a history of treatment-resistant schizophrenia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antipsicóticos
/
Clozapina
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Miocardite
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article