Involvement of NF-&#954;B/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.

Li, Guanghua; Qi, Li; Chen, Hui; Tian, Gendong

Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats.

Li, Guanghua; Qi, Li; Chen, Hui; Tian, Gendong.

Afiliação

Li G; Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Qi L; Department of Gastroenterology, Binzhou People's Hospital, Binzhou, China.
Chen H; Department of Gastroenterology, Binzhou People's Hospital, Binzhou, China.
Tian G; Department of Hepatobiliary Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

J Biochem Mol Toxicol ; 36(5): e23016, 2022 May.

Article em En | MEDLINE | ID: mdl-35239232

Assuntos

Carcinoma Hepatocelular; Isoflavonas; Neoplasias Hepáticas; Animais; Antioxidantes/metabolismo; Carcinogênese; Carcinoma Hepatocelular/induzido quimicamente; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/prevenção & controle; Dietilnitrosamina/toxicidade; Humanos; Neoplasias Hepáticas/induzido quimicamente; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/prevenção & controle; Masculino; NF-kappa B/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos; Ratos Wistar; Transdução de Sinais

Palavras-chave

PI3K/AKT pathway; apoptosis; diethylnitrosamine; hepatocellular carcinoma; prunetin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Isoflavonas / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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