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Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly.
Li, Hongjie; Janssens, Jasper; De Waegeneer, Maxime; Kolluru, Sai Saroja; Davie, Kristofer; Gardeux, Vincent; Saelens, Wouter; David, Fabrice P A; Brbic, Maria; Spanier, Katina; Leskovec, Jure; McLaughlin, Colleen N; Xie, Qijing; Jones, Robert C; Brueckner, Katja; Shim, Jiwon; Tattikota, Sudhir Gopal; Schnorrer, Frank; Rust, Katja; Nystul, Todd G; Carvalho-Santos, Zita; Ribeiro, Carlos; Pal, Soumitra; Mahadevaraju, Sharvani; Przytycka, Teresa M; Allen, Aaron M; Goodwin, Stephen F; Berry, Cameron W; Fuller, Margaret T; White-Cooper, Helen; Matunis, Erika L; DiNardo, Stephen; Galenza, Anthony; O'Brien, Lucy Erin; Dow, Julian A T; Jasper, Heinrich; Oliver, Brian; Perrimon, Norbert; Deplancke, Bart; Quake, Stephen R; Luo, Liqun; Aerts, Stein; Agarwal, Devika; Ahmed-Braimah, Yasir; Arbeitman, Michelle; Ariss, Majd M; Augsburger, Jordan; Ayush, Kumar; Baker, Catherine C; Banisch, Torsten.
Afiliação
  • Li H; Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Janssens J; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • De Waegeneer M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Kolluru SS; VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium.
  • Davie K; Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.
  • Gardeux V; VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium.
  • Saelens W; Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.
  • David FPA; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Brbic M; Department of Applied Physics, Stanford University, Stanford, CA, USA.
  • Spanier K; Chan Zuckerberg Biohub, San Francisco CA, USA.
  • Leskovec J; VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium.
  • McLaughlin CN; Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Xie Q; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
  • Jones RC; Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Brueckner K; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
  • Shim J; Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Tattikota SG; Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland.
  • Schnorrer F; Bioinformatics Competence Center, EPFL, Switzerland.
  • Rust K; Chan Zuckerberg Biohub, San Francisco CA, USA.
  • Nystul TG; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • Carvalho-Santos Z; VIB-KU Leuven Center for Brain and Disease Research, KU Leuven, Leuven 3000, Belgium.
  • Ribeiro C; Laboratory of Computational Biology, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.
  • Pal S; Chan Zuckerberg Biohub, San Francisco CA, USA.
  • Mahadevaraju S; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
  • Przytycka TM; Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Allen AM; Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.
  • Goodwin SF; Department of Bioengineering, Stanford University, Stanford, CA, USA.
  • Berry CW; Department of Applied Physics, Stanford University, Stanford, CA, USA.
  • Fuller MT; Chan Zuckerberg Biohub, San Francisco CA, USA.
  • White-Cooper H; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA.
  • Matunis EL; Department of Life Science, College of Natural Science, Hanyang University, 04763 Seoul, Republic of Korea.
  • DiNardo S; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
  • Galenza A; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
  • O'Brien LE; Aix-Marseille University, CNRS, IBDM (UMR 7288), Turing Centre for Living Systems, 13009 Marseille, France.
  • Dow JAT; Institute of Physiology and Pathophysiology, Department of Molecular Cell Physiology, Philipps-University, Marburg, Germany.
  • Jasper H; Department of Anatomy, University of California, San Francisco, CA 94143, USA.
  • Oliver B; Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
  • Perrimon N; Behavior and Metabolism Laboratory, Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
  • Deplancke B; National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
  • Quake SR; Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Kidney and Digestive Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Luo L; National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
  • Aerts S; Centre for Neural Circuits and Behaviour, University of Oxford, Oxford OX1 3SR, UK.
  • Agarwal D; Centre for Neural Circuits and Behaviour, University of Oxford, Oxford OX1 3SR, UK.
  • Ahmed-Braimah Y; Department of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Arbeitman M; Department of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ariss MM; Molecular Biosciences Division, Cardiff University, Cardiff CF10 3AX, UK.
  • Augsburger J; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Ayush K; Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Baker CC; The Penn Institute for Regenerative Medicine, Philadelphia, PA 19104, USA.
  • Banisch T; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science ; 375(6584): eabk2432, 2022 03 04.
Article em En | MEDLINE | ID: mdl-35239393
ABSTRACT
For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula Drosophilae, that includes 580,000 nuclei from 15 individually dissected sexed tissues as well as the entire head and body, annotated to >250 distinct cell types. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types between tissues, such as blood and muscle cells, reveals rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the Drosophila community and serves as a reference to study genetic perturbations and disease models at single-cell resolution.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Drosophila melanogaster / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Drosophila melanogaster / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article