Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction.

Bhat, Sanjana Mahadev; Massey, Nyzil; Shrestha, Denusha; Karriker, Locke A; Jelesijevic, Tomislav; Wang, Chong; Charavaryamath, Chandrashekhar

Bhat, Sanjana Mahadev; Massey, Nyzil; Shrestha, Denusha; Karriker, Locke A; Jelesijevic, Tomislav; Wang, Chong; Charavaryamath, Chandrashekhar.

Afiliação

Bhat SM; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Massey N; Immunobiology Interdepartmental Graduate Program, Iowa State University, Ames, IA, USA.
Shrestha D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Karriker LA; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Jelesijevic T; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Wang C; Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA, USA.
Charavaryamath C; Department of Comparative Biological Sciences, Louisiana State University, Baton Rouge, LA, USA.

Cell Tissue Res ; 388(2): 373-398, 2022 May.

Article em En | MEDLINE | ID: mdl-35244775

Assuntos

Proteína HMGB1; Poeira; Proteína HMGB1/metabolismo; Humanos; Inflamação/metabolismo; Mitocôndrias/metabolismo; Transcriptoma

Palavras-chave

Airway inflammation; HMGB1; Mitochondrial DNA; Mitochondrial dysfunction; Organic dust

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína HMGB1 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína HMGB1 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article