Releasing the trap: How the segregase p97 extracts PARP1 from chromatin.
Mol Cell
; 82(5): 889-890, 2022 03 03.
Article
em En
| MEDLINE
| ID: mdl-35245455
ABSTRACT
Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Inibidores de Poli(ADP-Ribose) Polimerases
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article