A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum.
Proc Natl Acad Sci U S A
; 119(11): e2107339119, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-35254903
ABSTRACT
SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
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MEDLINE
Assunto principal:
Diferenciação Celular
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Astrócitos
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Linhagem da Célula
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Corpo Estriado
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Reprogramação Celular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article