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SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
Douaud, Gwenaëlle; Lee, Soojin; Alfaro-Almagro, Fidel; Arthofer, Christoph; Wang, Chaoyue; McCarthy, Paul; Lange, Frederik; Andersson, Jesper L R; Griffanti, Ludovica; Duff, Eugene; Jbabdi, Saad; Taschler, Bernd; Keating, Peter; Winkler, Anderson M; Collins, Rory; Matthews, Paul M; Allen, Naomi; Miller, Karla L; Nichols, Thomas E; Smith, Stephen M.
Afiliação
  • Douaud G; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. gwenaelle.douaud@ndcn.ox.ac.uk.
  • Lee S; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Alfaro-Almagro F; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Arthofer C; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Wang C; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • McCarthy P; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Lange F; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Andersson JLR; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Griffanti L; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Duff E; OHBA, Wellcome Centre for Integrative Neuroimaging (WIN), Department of Psychiatry, University of Oxford, Oxford, UK.
  • Jbabdi S; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Taschler B; Department of Paediatrics, University of Oxford, Oxford, UK.
  • Keating P; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Winkler AM; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Collins R; Ear Institute, University College London, London, UK.
  • Matthews PM; National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
  • Allen N; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Miller KL; UK Dementia Research Institute and Department of Brain Sciences, Imperial College, London, UK.
  • Nichols TE; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Smith SM; FMRIB Centre, Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Nature ; 604(7907): 697-707, 2022 04.
Article em En | MEDLINE | ID: mdl-35255491
There is strong evidence of brain-related abnormalities in COVID-191-13. However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 participants of UK Biobank (aged 51-81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans-with 141 days on average separating their diagnosis and the second scan-as well as 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. We identified significant longitudinal effects when comparing the two groups, including (1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; (2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and (3) a greater reduction in global brain size in the SARS-CoV-2 cases. The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points. Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Humans / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article