Application of Population Pharmacokinetic Modeling, Exposure-Response Analysis, and Classification and Regression Tree Analysis to Support Dosage Regimen and Therapeutic Drug Monitoring of Plazomicin in Complicated Urinary Tract Infection Patients with Renal Impairment.

Zhuang, Luning; Wu, Kunyi; Jang, Seong H; Reynolds, Kellie S; Mishra, Shrimant; Iarikov, Dmitri

Zhuang, Luning; Wu, Kunyi; Jang, Seong H; Reynolds, Kellie S; Mishra, Shrimant; Iarikov, Dmitri.

Afiliação

Zhuang L; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Wu K; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Jang SH; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Reynolds KS; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Mishra S; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Iarikov D; Division of Anti-Infectives, Office of Infectious Diseases, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

Antimicrob Agents Chemother ; 66(4): e0207421, 2022 04 19.

Article em En | MEDLINE | ID: mdl-35258314

Assuntos

Insuficiência Renal; Infecções Urinárias; Adulto; Antibacterianos/farmacocinética; Monitoramento de Medicamentos; Feminino; Humanos; Masculino; Insuficiência Renal/induzido quimicamente; Insuficiência Renal/tratamento farmacológico; Sisomicina/análogos & derivados; Sisomicina/farmacocinética; Infecções Urinárias/tratamento farmacológico

Palavras-chave

classification and regression tree analysis; nephrotoxicity; plazomicin; renal impairment; therapeutic drug monitoring

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Insuficiência Renal Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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