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Copper-Catalyzed Bromo-cyanomethylative Cyclization of Enynes.
Zhu, Shaoqun; Pan, Yingjie; Sun, Yue; Hong, Xiaoyan; Chen, Xiaoyun; Han, Ying; Yan, Chaoguo; Shi, Yaocheng; Hou, Hong.
Afiliação
  • Zhu S; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Pan Y; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Sun Y; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Hong X; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Chen X; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212005, China.
  • Han Y; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Yan C; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Shi Y; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
  • Hou H; School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225009, China.
J Org Chem ; 87(6): 4455-4459, 2022 Mar 18.
Article em En | MEDLINE | ID: mdl-35258964
ABSTRACT
A copper-catalyzed bromo-cyanomethylative cyclization of 1,6-enynes is demonstrated. The treatment of 2-bromoacetonitrile with CuI enables the alkyl radical generation and triggers the radical addition/cyclization/bromination sequence, giving various vinyl C-Br bonds containing functionalized heterocycles in good yields.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article