Gain of gene regulatory network interconnectivity at the origin of vertebrates.
Proc Natl Acad Sci U S A
; 119(11): e2114802119, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-35263228
ABSTRACT
SignificanceIn this manuscript, we address an essential question in developmental and evolutionary biology How have changes in gene regulatory networks contributed to the invertebrate-to-vertebrate transition? To address this issue, we perturbed four signaling pathways critical for body plan formation in the cephalochordate amphioxus and in zebrafish and compared the effects of such perturbations on gene expression and gene regulation in both species. Our data reveal that many developmental genes have gained response to these signaling pathways in the vertebrate lineage. Moreover, we show that the interconnectivity between these pathways is much higher in zebrafish than in amphioxus. We conclude that this increased signaling pathway complexity likely contributed to vertebrate morphological novelties during evolution.
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Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
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Regulação da Expressão Gênica no Desenvolvimento
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Redes Reguladoras de Genes
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Anfioxos
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article