Small Molecule Accurate Recognition Technology accelerated isolation of structurally diverse sesquiterpenes from Litsea lancilimba Merr.
Fitoterapia
; 158: 105168, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35263630
ABSTRACT
Four undescribed sesquiterpenes (1-4) and 20 known sesquiterpenes (5-24) were obtained from the fruits of Litsea lancilimba Merr. by Small Molecule Accurate Recognition Technology (SMART). The gross structures and the relative configurations of the new compounds were deduced by spectroscopic data analysis. The absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra data. All compounds were screened for their neuroprotective effects against H2O2-induced SH-SY5Y cells injury. Compounds 2, 3, 7, 8 and 13 exhibited comparable neuroprotective activity to the positive trolox at 50 µM.
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Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
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Fármacos Neuroprotetores
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Litsea
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article