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Chiral rhodium(III)-azobenzene complexes as photoswitchable DNA molecular locks.
Lin, Mingwei; Zou, Shanshan; Li, Tingzhen; Karges, Johannes; Chen, Yu; Zhao, Yukun; Ji, Liangnian; Chao, Hui.
Afiliação
  • Lin M; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
  • Zou S; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
  • Li T; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
  • Karges J; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
  • Chen Y; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
  • Zhao Y; Department of Dermatology, The Eastern Division of the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, P. R. China. zhaoyukun7288569@sina.com.
  • Ji L; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
  • Chao H; MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, P. R. China. ceschh@mail.sysu.edu.cn.
Chem Commun (Camb) ; 58(27): 4324-4327, 2022 Mar 31.
Article em En | MEDLINE | ID: mdl-35274116
ABSTRACT
Chiral rhodium(III)-azobenzene complexes that are able to intercalate into DNA were developed. Upon light exposure, the azobenzene moiety of the metal complexes can photoisomerize from the trans-form to the cis-form, and strongly stabilize the DNA double-helix and modulate DNA transcription. This study presents the first example of metal-based photoswitchable DNA molecular locks.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ródio Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ródio Idioma: En Ano de publicação: 2022 Tipo de documento: Article