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Upregulation of PODXL and ITGB1 in pancreatic cancer tissues preoperatively obtained by EUS-FNAB correlates with unfavorable prognosis of postoperative pancreatic cancer patients.
Taniuchi, Keisuke; Ueno, Makoto; Yokose, Tomoyuki; Sakaguchi, Masahiko; Yoshioka, Reiko; Ogasawara, Mitsunari; Kosaki, Takuhiro; Naganuma, Seiji; Furihata, Mutsuo.
Afiliação
  • Taniuchi K; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Ueno M; Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Yokose T; Department of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
  • Sakaguchi M; Faculty of Information and Communication Engineering, Osaka Electro-Communication University, Osaka, Japan.
  • Yoshioka R; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Ogasawara M; Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Kosaki T; Department of Endoscopic Diagnostics and Therapeutics, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Naganuma S; Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Furihata M; Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
PLoS One ; 17(3): e0265172, 2022.
Article em En | MEDLINE | ID: mdl-35275973
ABSTRACT
The upregulation of PODXL and ITGB1 in surgically resected pancreatic cancer tissues is correlated with an unfavorable postoperative prognosis. The aim of this study was to investigate whether PODXL and ITGB1 are useful preoperative markers for the prognosis of postoperative pancreatic cancer patients in comparison with the TNM staging system. Immunohistochemistry was performed using anti-PODXL and anti-ITGB1 antibodies on 24 pancreatic cancer tissue samples preoperatively obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy. Cox proportional hazards regression analysis was performed to investigate if the UICC TNM stage and upregulation of PODXL and ITGB1 were correlated with postoperative overall survival rates. Univariate analysis revealed that PODXL, TNM stage, lymphatic invasion and the combination of PODXL with ITGB1 are correlated with postoperative survival. Multivariate analysis demonstrated TNM stage and the combination of PODXL with ITGB1 to be correlated with postoperative survival, and the combination of PODXL with ITGB1 most accurately predicted the postoperative outcomes of pancreatic cancer patients before resection. Therefore, upregulation of PODXL and ITGB1 may indicate preoperative neoadjuvant therapy for pancreatic cancer patients by accurately predicting the postoperative prognosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article