UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice.

Xiong, Mengneng; Zhou, Shumin; Feng, Shenglei; Gui, Yiqian; Li, Jinmei; Wu, Yanqing; Dong, Juan; Yuan, Shuiqiao

UHRF1 is indispensable for meiotic sex chromosome inactivation and interacts with the DNA damage response pathway in mice.

Xiong, Mengneng; Zhou, Shumin; Feng, Shenglei; Gui, Yiqian; Li, Jinmei; Wu, Yanqing; Dong, Juan; Yuan, Shuiqiao.

Afiliação

Xiong M; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhou S; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Feng S; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gui Y; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Li J; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wu Y; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong J; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuan S; Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Biol Reprod ; 107(1): 168-182, 2022 07 25.

Article em En | MEDLINE | ID: mdl-35284939

Assuntos

Proteínas Estimuladoras de Ligação a CCAAT; Pareamento Cromossômico; Cromossomos Sexuais; Ubiquitina-Proteína Ligases; Animais; Proteínas Estimuladoras de Ligação a CCAAT/genética; Proteínas Estimuladoras de Ligação a CCAAT/metabolismo; Dano ao DNA; Masculino; Meiose/genética; Camundongos; Cromossomos Sexuais/genética; Espermatócitos/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

DNA damage response; UHRF1; male infertility; meiosis; meiotic sex chromosome inactivation (MSCI)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromossomos Sexuais / Proteínas Estimuladoras de Ligação a CCAAT / Pareamento Cromossômico / Ubiquitina-Proteína Ligases Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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