Lipase-catalyzed hydrazine insertion for the synthesis of N'-alkyl benzohydrazides.
Biotechnol Appl Biochem
; 70(1): 130-136, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-35285069
ABSTRACT
N'-alkyl benzohydrazides are classic organic compounds that have been widely utilized in organic chemistry. In this study, an efficient method was developed for the synthesis of N'-alkyl benzohydrazides by hydrazine insertion catalyzed by lipase. Under the optimal conditions (Morita-Baylis-Hillman ketone [1 mmol], phenylhydrazine [1.3 mmol], N,N-dimethylformamide [2 ml], lipase [20 mg], room temperature, 12 h), satisfactory yields (71-97%) and substrate tolerance were obtained when porcine pancreatic lipase was used as biocatalyst. These findings imply the great potential for the lipase-catalyzed synthesis of N'-alkyl benzohydrazides and extend the utilization of lipase in organic chemistry.
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Base de dados:
MEDLINE
Assunto principal:
Cetonas
/
Lipase
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article