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Large-scale design and refinement of stable proteins using sequence-only models.
Singer, Jedediah M; Novotney, Scott; Strickland, Devin; Haddox, Hugh K; Leiby, Nicholas; Rocklin, Gabriel J; Chow, Cameron M; Roy, Anindya; Bera, Asim K; Motta, Francis C; Cao, Longxing; Strauch, Eva-Maria; Chidyausiku, Tamuka M; Ford, Alex; Ho, Ethan; Zaitzeff, Alexander; Mackenzie, Craig O; Eramian, Hamed; DiMaio, Frank; Grigoryan, Gevorg; Vaughn, Matthew; Stewart, Lance J; Baker, David; Klavins, Eric.
Afiliação
  • Singer JM; Two Six Technologies, Arlington, Virginia, United States of America.
  • Novotney S; Two Six Technologies, Arlington, Virginia, United States of America.
  • Strickland D; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America.
  • Haddox HK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Leiby N; Two Six Technologies, Arlington, Virginia, United States of America.
  • Rocklin GJ; Department of Pharmacology and Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
  • Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Motta FC; Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America.
  • Cao L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Strauch EM; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America.
  • Chidyausiku TM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Ford A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Ho E; Texas Advanced Computing Center, Austin, Texas, United States of America.
  • Zaitzeff A; Two Six Technologies, Arlington, Virginia, United States of America.
  • Mackenzie CO; Quantitative Biomedical Sciences Graduate Program, Dartmouth College, Hanover, New Hampshire, United States of America.
  • Eramian H; Netrias, Cambridge, Massachusetts, United States of America.
  • DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Grigoryan G; Departments of Computer Science and Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America.
  • Vaughn M; Texas Advanced Computing Center, Austin, Texas, United States of America.
  • Stewart LJ; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Baker D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America.
  • Klavins E; Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America.
PLoS One ; 17(3): e0265020, 2022.
Article em En | MEDLINE | ID: mdl-35286324
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Redes Neurais de Computação Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Redes Neurais de Computação Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article