TCA cycle off, ATF4 on for metabolic homeostasis.

Mahor, Durga; Pandey, Rishikesh; Bulusu, Vinay

Mahor, Durga; Pandey, Rishikesh; Bulusu, Vinay.

Afiliação

Mahor D; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India.
Pandey R; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India.
Bulusu V; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India. Electronic address: vbulusu@iiserbpr.ac.in.

Trends Biochem Sci ; 47(7): 558-560, 2022 07.

Article em En | MEDLINE | ID: mdl-35292185

ABSTRACT

ABSTRACT

Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.

Assuntos

Aminoácidos; Ciclo do Ácido Cítrico; Homeostase; Redes e Vias Metabólicas; Oxirredução

Palavras-chave

ATF4; TCA cycle; fumarate hydratase; glutathione synthesis; integrated stress response; succinate dehydrogenase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciclo do Ácido Cítrico / Aminoácidos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciclo do Ácido Cítrico / Aminoácidos Idioma: En Ano de publicação: 2022 Tipo de documento: Article