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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses.
Mittler, Eva; Wec, Anna Z; Tynell, Janne; Guardado-Calvo, Pablo; Wigren-Byström, Julia; Polanco, Laura C; O'Brien, Cecilia M; Slough, Megan M; Abelson, Dafna M; Serris, Alexandra; Sakharkar, Mrunal; Pehau-Arnaudet, Gerard; Bakken, Russell R; Geoghegan, James C; Jangra, Rohit K; Keller, Markus; Zeitlin, Larry; Vapalahti, Olli; Ulrich, Rainer G; Bornholdt, Zachary A; Ahlm, Clas; Rey, Felix A; Dye, John M; Bradfute, Steven B; Strandin, Tomas; Herbert, Andrew S; Forsell, Mattias N E; Walker, Laura M; Chandran, Kartik.
Afiliação
  • Mittler E; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Wec AZ; Adimab, LLC, Lebanon, NH 03766, USA.
  • Tynell J; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Guardado-Calvo P; Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland.
  • Wigren-Byström J; Structural Virology Unit, Department of Virology, Institut Pasteur, Paris 75724, France.
  • Polanco LC; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • O'Brien CM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Slough MM; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Abelson DM; The Geneva Foundation, Tacoma, WA 98402, USA.
  • Serris A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Sakharkar M; Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
  • Pehau-Arnaudet G; Structural Virology Unit, Department of Virology, Institut Pasteur, Paris 75724, France.
  • Bakken RR; Adimab, LLC, Lebanon, NH 03766, USA.
  • Geoghegan JC; Structural Virology Unit, Department of Virology, Institut Pasteur, Paris 75724, France.
  • Jangra RK; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Keller M; Adimab, LLC, Lebanon, NH 03766, USA.
  • Zeitlin L; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Vapalahti O; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.
  • Ulrich RG; Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
  • Bornholdt ZA; Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland.
  • Ahlm C; Veterinary Biosciences, Veterinary Faculty, University of Helsinki, Helsinki, Finland.
  • Rey FA; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-Insel Riems, Germany.
  • Dye JM; Deutsches Zentrum für Infektionsforschung, Partner site Hamburg-Lübeck- Borstel-Riems, Greifswald-Insel Riems, Germany.
  • Bradfute SB; Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.
  • Strandin T; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
  • Herbert AS; Structural Virology Unit, Department of Virology, Institut Pasteur, Paris 75724, France.
  • Forsell MNE; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Walker LM; Center for Global Health, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.
  • Chandran K; Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland.
Sci Transl Med ; 14(636): eabl5399, 2022 03 16.
Article em En | MEDLINE | ID: mdl-35294259
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Orthohantavírus / Infecções por Hantavirus / Virus Puumala / Febre Hemorrágica com Síndrome Renal Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Orthohantavírus / Infecções por Hantavirus / Virus Puumala / Febre Hemorrágica com Síndrome Renal Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article