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Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
Azevedo, Carla; Teku, Gabriel; Pomeshchik, Yuriy; Reyes, Juan F; Chumarina, Margarita; Russ, Kaspar; Savchenko, Ekaterina; Hammarberg, Anna; Lamas, Nuno Jorge; Collin, Anna; Gouras, Gunnar K; Klementieva, Oxana; Hallbeck, Martin; Taipa, Ricardo; Vihinen, Mauno; Roybon, Laurent.
Afiliação
  • Azevedo C; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Teku G; Protein Structure and Bioinformatics, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Pomeshchik Y; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Reyes JF; Department of Clinical Pathology, Linköping University, 58185 Linköping, Sweden.
  • Chumarina M; Department of Biomedical and Clinical Sciences, Linköping University, 58185 Linköping, Sweden.
  • Russ K; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Savchenko E; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Hammarberg A; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Lamas NJ; iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Collin A; Life and Health Sciences Research Institute, School of Medicine, University of Minho, 4710-057 Braga, Portugal.
  • Gouras GK; Life and Health Sciences Research Institute/3B's, PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal.
  • Klementieva O; Anatomic Pathology Service, Pathology Department, Centro Hospitalar e Universitário do Porto, 4099-001 Porto, Portugal.
  • Hallbeck M; Department of Clinical Genetics and Pathology, Region Skåne Office for Medical Services, 22185 Lund, Sweden.
  • Taipa R; Experimental Dementia Research Unit, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Vihinen M; Medical Micro-spectroscopy, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
  • Roybon L; Department of Clinical Pathology, Linköping University, 58185 Linköping, Sweden.
Proc Natl Acad Sci U S A ; 119(12): e2111405119, 2022 03 22.
Article em En | MEDLINE | ID: mdl-35294277
ABSTRACT
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Atrofia de Múltiplos Sistemas / Células-Tronco Pluripotentes Induzidas / Sinucleinopatias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Atrofia de Múltiplos Sistemas / Células-Tronco Pluripotentes Induzidas / Sinucleinopatias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article