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Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases.
Liang, Geoffrey; Zhu, Feng; Mirza, Ali I; Bar-Or, Amit; Bernstein, Charles N; Bonner, Christine; Forbes, Jessica D; Graham, Morag; Hart, Janace; Knox, Natalie C; Marrie, Ruth Ann; O'Mahony, Julia; Van Domselaar, Gary; Yeh, E Ann; Zhao, Yinshan; Banwell, Brenda; Waubant, Emmanuelle; Tremlett, Helen.
Afiliação
  • Liang G; Division of Neurology, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada/The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
  • Zhu F; Division of Neurology, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada/The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
  • Mirza AI; Division of Neurology, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada/The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
  • Bar-Or A; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bernstein CN; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences and University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.
  • Bonner C; National Microbiology Laboratory, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
  • Forbes JD; Roy Romanow Provincial Laboratory, Regina, SK, Canada/Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
  • Graham M; National Microbiology Laboratory, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada/Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, Winnipeg, MB, Canada.
  • Hart J; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Knox NC; National Microbiology Laboratory, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada/Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, Winnipeg, MB, Canada.
  • Marrie RA; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, Winnipeg, Manitoba, Canada.
  • O'Mahony J; The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Van Domselaar G; National Microbiology Laboratory, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada/Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, Winnipeg, MB, Canada.
  • Yeh EA; The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
  • Zhao Y; Division of Neurology, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada/The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
  • Banwell B; Division of Neurology, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Waubant E; Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Tremlett H; Division of Neurology, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada/The Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada.
Mult Scler ; 28(11): 1819-1824, 2022 10.
Article em En | MEDLINE | ID: mdl-35296164
ABSTRACT

OBJECTIVE:

Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS).

METHODS:

A total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed.

RESULTS:

Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus - Solobacterium did (p = 0.001).

CONCLUSIONS:

The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Esclerose Múltipla Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Esclerose Múltipla Limite: Child / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article