Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.
Nat Neurosci
; 25(5): 555-560, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35301477
ABSTRACT
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Crânio
/
Medula Óssea
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article