Monoterpene indole N-oxide alkaloids from Tabernaemontana corymbosa and their antimicrobial activity.
Fitoterapia
; 158: 105178, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35302006
ABSTRACT
Tabernaemontana corymbosa is a traditional folk medicine. In our research, six monoterpene indole N-oxide alkaloids and their parent alkaloids were obtained from the stem bark of T. corymbosa, including seven new alkaloids (1-7) and five known alkaloids (8-12). Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, and DP4+ probability analyses. The antimicrobial activity of the obtained compounds was evaluated, among which alkaloids 4, 8, 12 showed significant antimicrobial activity against Staphylococcus aureus with an MIC value of 6.25 µg/mL, while alkaloids 11, 12 showed moderate antimicrobial activity against Bacillus subtilis with an MIC value of 25 µg/mL.
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Base de dados:
MEDLINE
Assunto principal:
Tabernaemontana
/
Alcaloides
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article