(Hetero)aryl-SVI Fluorides: Synthetic Development and Opportunities.
Angew Chem Int Ed Engl
; 61(23): e202200904, 2022 06 07.
Article
em En
| MEDLINE
| ID: mdl-35303387
ABSTRACT
(Hetero)arylsulfur compounds where the S atom is in the oxidation state VI represent a large percentage of the molecular functionalities present in organic chemistry. More specifically, (hetero)aryl-SVI fluorides have recently received enormous attention because of their potential as chemical biology probes, as a result of their reactivity in a simple, modular, and efficient manner. Whereas the synthesis and application of the levelâ
1 fluorination at SVI atoms (sulfonyl and sulfonimidoyl fluorides) have been widely studied and reviewed, the synthetic strategies towards higher levels of fluorination (levelsâ
2 to 5) are somewhat more limited. This Minireview evaluates and summarizes the progress in the synthesis of highly fluorinated aryl-SVI compounds at all levels, discussing synthetic strategies, reactivity, the advantages and disadvantages of the synthetic procedures, the proposed mechanisms, and the potential upcoming opportunities.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Halogenação
/
Fluoretos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article