MAPK-Activated Protein Kinases: Servant or Partner?
Annu Rev Biochem
; 91: 505-540, 2022 06 21.
Article
em En
| MEDLINE
| ID: mdl-35303787
Mitogen-activated protein kinase (MAPK)-activated protein kinases (MAPKAPKs) are defined by their exclusive activation by MAPKs. They can be activated by classical and atypical MAPKs that have been stimulated by mitogens and various stresses. Genetic deletions of MAPKAPKs and availability of highly specific small-molecule inhibitors have continuously increased our functional understanding of these kinases. MAPKAPKs cooperate in the regulation of gene expression at the level of transcription; RNA processing, export, and stability; and protein synthesis. The diversity of stimuli for MAPK activation, the crosstalk between the different MAPKs and MAPKAPKs, and the specific substrate pattern of MAPKAPKs orchestrate immediate-early and inflammatory responses in space and time and ensure proper control of cell growth, differentiation, and cell behavior. Hence, MAPKAPKs are promising targets for cancer therapy and treatments for conditions of acute and chronic inflammation, such as cytokine storms and rheumatoid arthritis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinases de Proteína Quinase Ativadas por Mitógeno
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article