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Structural characterization of a polysaccharide from Trametes sanguinea Lloyd with immune-enhancing activity via activation of TLR4.
Zhang, Mengting; Yan, Mengxia; Yang, Jiaqian; Li, Fenfen; Wang, Yiran; Feng, Kaiyuan; Wang, Sanying; Lin, Nengming; Wang, Yiqi; Yang, Bo.
Afiliação
  • Zhang M; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Yan M; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Yang J; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Li F; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Wang Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Feng K; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China.
  • Wang S; Zhejiang Provincial Key Lab of Geriatrics, Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310030, PR China.
  • Lin N; Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China. Electronic address: lnm1013@zju.edu.cn.
  • Wang Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China. Electronic address: wangyiqi2011@126.com.
  • Yang B; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No. 260 Baichuan Street, Hangzhou 311402, PR China. Electronic address: ybtcm@zcmu.edu.cn.
Int J Biol Macromol ; 206: 1026-1038, 2022 May 01.
Article em En | MEDLINE | ID: mdl-35306017
A bioactive polysaccharide (TS2-2A) with a molecular weight of 15 kDa was isolated from Trametes sanguinea Lloyd, a medicinal food homologous fungus, by water extraction-alcohol precipitation and chromatographic separation. NMR analysis of polysaccharide and MS/MS analysis of its oligosaccharide indicated that TS2-2A featured a novel straight chain with a backbone of 1,3-α-d-glucopyranose and 1,4-ß-d-glucopyranose at a molar ratio of 1:4. Moreover, TS2-2A, recognized by Toll-like receptor 4 (TLR4), stimulated RAW 264.7 macrophages to release related cytokines and contributed to immune-enhancing effects. Briefly, with remarkable immune-enhancing activity and noncytotoxicity, TS2-2A was proposed to be a potential immune enhancer for supplementing drugs or functional foods.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Trametes Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 4 Toll-Like / Trametes Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article