Reprogramming RNA processing: an emerging therapeutic landscape.
Trends Pharmacol Sci
; 43(5): 437-454, 2022 05.
Article
em En
| MEDLINE
| ID: mdl-35331569
ABSTRACT
The production of a mature mRNA requires coordination of multiple processing steps, which ultimately control its content, localization, and stability. These steps include some of the largest macromolecular machines in the cell, which were, until recently, considered undruggable due to their biological complexity. Building from an expanded understanding of the underlying mechanisms that drive these processes, a new wave of therapeutics is seeking to target RNA processing. With a focus on impacting gene regulation at the RNA level, such modalities offer potential for sequence-specific resolution in drug design. Here, we review our current understanding of RNA-processing events and their role in gene regulation, with a focus on the therapeutic opportunities that have emerged within this landscape.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento Pós-Transcricional do RNA
/
Oligonucleotídeos Antissenso
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article