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Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.
Li, Junhua; Zhang, Cheng; Xu, Hongrui; Wang, Chao; Dong, Ruibo; Shen, Hui; Zhuang, Xiaoxi; Chen, Xiaoshan; Li, Qiu; Lu, Jibu; Zhang, Maofeng; Wu, Xishan; Loomes, Kerry M; Zhou, Yulai; Zhang, Yan; Liu, Jinsong; Xu, Yong.
Afiliação
  • Li J; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Zhang C; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.
  • Xu H; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Wang C; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Dong R; Guangdong Provincial Key Laboratory of Biocomputing, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Guangzhou Medical University, Chinese Academy of Sciences, Guangzhou 510530, China.
  • Shen H; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Zhuang X; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.
  • Chen X; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Li Q; School of Pharmaceutical Sciences, Jilin University, No. 1266 Fujin Road, Chaoyang District, Changchun, Jilin 130021, China.
  • Lu J; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Zhang M; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.
  • Wu X; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Loomes KM; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Zhou Y; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.
  • Zhang Y; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
  • Liu J; University of Chinese Academy of Sciences, No. 19 Yuquan Road, Beijing 100049, China.
  • Xu Y; Center for Chemical Biology and Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190 Kaiyuan Avenue, Guangzhou 510530, China.
J Med Chem ; 65(7): 5760-5799, 2022 04 14.
Article em En | MEDLINE | ID: mdl-35333526
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article